What is a common consequence of having biliary obstruction?

Biliary obstruction occurs when there is a blockage in the bile ducts, which can be due to a variety of reasons such as gallstones, tumors, or strictures. One of the primary functions of bile is to aid in the digestion and absorption of fats and fat-soluble vitamins, and it also plays a critical role in the excretion of bilirubin.

When bile flow is obstructed, bilirubin, which is produced from the breakdown of hemoglobin in red blood cells, cannot be effectively excreted into the intestine. As a result, bilirubin accumulates in the bloodstream, leading to elevated levels known as hyperbilirubinemia. This condition can manifest clinically as jaundice, which is characterized by yellowing of the skin and eyes, and can also affect the urine and stool color. Hence, hyperbilirubinemia is a direct and common consequence of biliary obstruction. The accumulation of bilirubin in the body signifies that normal metabolism and excretion processes have been disrupted due to the obstruction.